Aqilion sells shareholdings in portfolio company Glactone Pharma

AQILION AB is selling its entire stake in the portfolio company Glactone Pharma AB to Daniel Lifveredson Invest AB. The purchase price is divided into a smaller amount as initial payment at the time of takeover and an additional payment based on Glactone Pharma’s future performance.

Glactone Pharma AB was founded in 2012 as a project company within what was then known as Partners för Utvecklingsinvesteringar inom Life Sciences, P.U.L.S. AB, now known as AQILION AB. Glactone Pharma develops innovative new drug candidates for treatment of late-stage prostate cancer (castration-resistant prostate cancer). The innovators’ idea is based on a naturally occurring molecule that has been shown to bind to and block STAT3, which is overactive in cancer cells, and contributes to the unrestrained growth of castration-resistant prostate cancer cells. Since STAT3 is involved in many of the central disease processes in cancer, STAT3 blocking is considered to be one of the most promising new methods for treating various types of cancer.

In accordance with Aqilion’s strategy and business model, the company has inventoried its respective holdings in the portfolio companies. Aqilion’s assessment is that Glactone Pharma will have better opportunities and conditions for its successful continued development under a new principal owner, for which reason Aqilion has now sold its entire stake in the company.

“Glactone Pharma’s research and development is both thorough and innovative. With a new principal owner in place, the company will have the opportunity to develop both existing intellectual property rights and completely new drug candidates. I look forward to following Glactone Pharma’s progress, since its innovators, along with its management and owners, now have excellent prospects for successful future development,” says Sarah Fredriksson, CEO of Aqilion.

For more information, please contact
Sarah Fredriksson, CEO, AQILION AB, +46 (0)70 261 4575, sarah.fredriksson@aqilion.com

About AQILION AB
Aqilion is a Swedish life science company that identifies unique pharmaceutical projects at an early phase in the drug discovery process and develops them in preparation for clinical trials. The goal is to demonstrate the clinical and commercial potential of the medical innovation to attract industrial partners and buyers, who in turn have the capacity to continue clinical development and take the product to market. The business model is based on involvement at an early stage and close collaboration with the innovator, regardless of whether the project is initiated by an external researcher, internal development project, or industrial partner. Aqilion prefers projects aimed at niche markets. Specialty medications (high-cost, high complexity and/or high touch drugs) and orphan drugs (drugs to treat diseases so rare that they would be unprofitable to produce without government assistance) are particularly interesting. Aqilion has its headquarters in Helsingborg.

Please visit www.aqilion.com.


Aqilion strengthens its portfolio with two innovative pharmaceutical projects in the fields of inflammation and oncology

Aqilion is strengthening its portfolio with the addition of two innovative preclinical projects, Alhena and Alnitak. The company is overseeing the two pharmaceutical projects, which both fall under Aqilion’s new focus area: inflammation at the interface of oncology and immunology.

The Alhena project aims to develop a “PROTAC” drug against a target protein that is central to some cancers. PROTAC is an acronym for proteolysis-targeting chimera (PROTAC). Basically, the technology uses the cell’s own system to break down a certain target protein in the cell, instead of just trying to block its action. The Alhena project involves combination therapy in immuno-oncology with an initial focus on aggressive, treatment-resistant “triple negative breast cancer.”

The Alnitak project has two interesting applications. The goal is to develop drug candidates that bind to a target protein that is essential for both malignant disease development and for inflammatory conditions. A successful project can therefore help to develop new medications to treat orphan drug indications in the field of autoinflammatory diseases, as well as new combination therapies within the field of oncology, primarily intestinal cancer.

Aqilion oversees both projects in collaboration with selected contract research organizations (CROs) specializing in innovative early pharmaceutical projects. The objective is to develop both projects into attractive preclinical projects and then identify a partner for the clinical and commercial development.

“We are proud to announce that Aqilion is now launching two innovative pharmaceutical projects that are both based on new knowledge from the pharmaceutical industry and academic research in the fields of oncology, inflammation and immunology. I am convinced that our new area of focus and approach will result in synergies, greater knowledge within the team and strong collaboration in the future with selected partners and customers in industry. I look forward to reporting the results moving forward,” says Sarah Fredriksson, CEO of AQILION AB.

Aqilion is in a transitional phase that has entailed a new start based on solid analysis and culminating in a forward-looking strategy. Earlier this year, the company changed its name to Aqilion in acknowledgement of this transition. The path has included recruitment of a strengthened team, as well as an inventory and validation of the projects Aqilion had in its portfolio at that time. Willingness to build a business model that delivers, combined with the courage to discontinue those projects that do not meet set criteria, will be crucial to its success.

For more information, please contact
Sarah Fredriksson, CEO, AQILION AB, +46 (0)70 261 4575, sarah.fredriksson@aqilion.com

About AQILION AB
Aqilion is a Swedish life science company that identifies unique pharmaceutical projects at an early phase in the drug discovery process and develops them in preparation for clinical trials. The goal is to demonstrate the clinical and commercial potential of the medical innovation to attract industrial partners and buyers, who in turn have the capacity to continue clinical development and take the product to market. The business model is based on involvement at an early stage and close collaboration with the innovator, regardless of whether the project is initiated by an external researcher, internal development project, or industrial partner. Aqilion prefers projects aimed at niche markets. Specialty medications and orphan drugs are of particular interest. Aqilion has its headquarters in Helsingborg. Please visit www.aqilion.com.

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Aqilion project company Adenovir Pharma liquidated

Today AQILION AB announced that the extraordinary general meeting of the project company Adenovir Pharma AB resolved to liquidate the company. According to the decision, liquidation will begin on November 1, 2019. 

Adenovir Pharma developed an antiviral medication (APD-209) to treat and potentially even to prevent the contagious eye disease epidemic keratoconjunctivitis (EKC), which is caused by a virus. The phase 2 trial with ADP-209 did not provide conclusive results since the number of patients in the study was insufficient to achieve statistical significance. This has made continued development and the possibility of selling the project difficult.

 

It is always a disappointment when a project does not develop as desired. A successful drug discovery project requires solid science and step-by-step data-driven research and development. In the case of Adenovir Pharma, the company was founded based on solid innovative research and the project has developed according to plan until the phase 2 study. Demonstrating that a completely new innovative treatment works in patients is the goal throughout the entire development phase and no matter how a study is planned, you can only learn how effective the treatment is after completing the trial. In the case of Adenovir Pharma, the study results were not sufficient to motivate either a buyer or the existing owners to continue to advance the project to new clinical trials, which has contributed to the decision for voluntary liquidation,” says Sarah Fredriksson, chairman of the board of Adenovir Pharma AB and CEO of AQILION AB.

 

Adenovir Pharma AB was founded in 2008 by AQILION AB (at that time under the company name Partners för Utvecklingsinvesteringar inom Life Sciences, P.U.L.S. AB) together with its partners and the innovators behind the project idea. Aqilion continued to be the largest owner of Adenovir Pharma since its inception.

 

For more information, please contact:

Sarah Fredriksson, chairman of the board of Adenovir Pharma AB and CEO of AQILION AB,
+46(0)70 261 4575,
sarah.fredriksson@aqilion.com

 

About AQILION AB

Aqilion is a Swedish life science company that identifies unique pharmaceutical projects at an early phase in the drug discovery process and develops them in preparation for clinical trials. The goal is to demonstrate the clinical and commercial potential of the medical innovation to attract industrial partners and buyers, who in turn have the capacity to continue clinical development and take the product to market. The business model is based on involvement at an early stage and close collaboration with the innovator, regardless of whether the project is initiated by an external researcher, internal development project, or industrial partner. Aqilion prefers

projects aimed at niche markets. Specialty medications and orphan drugs are of particular interest.

Aqilion has its headquarters in Helsingborg. Please visit www.aqilion.com

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